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β-Adrenergic Blockade during Memory Retrieval in Humans Evokes a Sustained Reduction of Declarative Emotional Memory Enhancement
- Source :
- The Journal of Neuroscience
- Publication Year :
- 2010
- Publisher :
- Society for Neuroscience, 2010.
-
Abstract
- Memory enhancement for emotional events is dependent on amygdala activation and noradrenergic modulation during learning. A potential role for noradrenaline (NE) during retrieval of emotional memory is less well understood. Here, we report that administration of the β-adrenergic receptor antagonist propranolol at retrieval abolishes a declarative memory enhancement for emotional items. Critically, this effect persists at a subsequent 24 h memory test, in the absence of propranolol. Thus, these findings extend our current understanding of the role of NE in emotional memory to encompass effects at retrieval, and provide face validity to clinical interventions using β-adrenergic antagonists in conjunction with reactivation of unwanted memories in anxiety-related disorders.
- Subjects :
- Adult
Male
medicine.drug_class
Adrenergic beta-Antagonists
Emotions
Adrenergic
Propranolol
Amygdala
Article
Young Adult
Memory
Receptors, Adrenergic, beta
Emotional memory
medicine
Explicit memory
Humans
General Neuroscience
Receptor antagonist
medicine.anatomical_structure
Mental Recall
Female
Memory consolidation
Psychology
medicine.drug
Cognitive psychology
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....b10b4c6006d68447749532d70777bc80