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Neck circumference as an independent predictor for NAFLD among postmenopausal women with normal body mass index
- Source :
- Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-10 (2021), Nutrition & Metabolism
- Publication Year :
- 2021
- Publisher :
- Research Square Platform LLC, 2021.
-
Abstract
- Background Neck circumference, a proxy for upper-body subcutaneous fat, is a unique and pathogenic fat depot that confers additional metabolic risk. The purpose of present study was to determine whether neck circumference associates with nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with normal body mass index. Methods A cross-sectional survey (n = 2492) and a 3.1-year follow-up investigation (n = 1354) were conducted among Chinese postmenopausal women with normal BMI (18.5 to 2). Neck circumference was measured horizontally at the lower margin of the laryngeal prominence. Results In the cross-sectional analysis, large neck circumference was associated with the presence of NAFLD (odds ratio 2.28; 95% CI 1.74–2.98; highest tertile versus lowest tertile) after adjustment for confounding factors. Among 1354 subjects without the NAFLD at baseline, 429 (31.7%) incident NAFLD cases occurred at 3.1 years. Neck circumference was positively associated with triglycerides, homeostasis model assessment of insulin resistance, C-reactive protein, and negatively associated with high-density lipoprotein cholesterol and adiponectin. Individuals with large baseline neck circumference had a significantly higher risk of NAFLD than those with small neck circumference. The multivariable adjusted hazard ratio was 1.42 (95% CI 1.15–1.97; p for trend = 0.004) for the highest versus the lowest tertile of neck circumference, and was 1.22 (95% CI 1.10–1.41; p = 0.006) per 1-standard deviation increment in neck circumference. Conclusions Among postmenopausal women with normal BMI, relatively large neck circumference levels are associated with an increased risk of NAFLD.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
030209 endocrinology & metabolism
lcsh:TX341-641
Clinical nutrition
030204 cardiovascular system & hematology
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Internal medicine
Nonalcoholic fatty liver disease
Medicine
lcsh:RC620-627
Nutrition and Dietetics
Adiponectin
business.industry
Research
Hazard ratio
Confounding
Normal body mass index
Odds ratio
Circumference
medicine.disease
Postmenopausal women
lcsh:Nutritional diseases. Deficiency diseases
Neck circumference
business
lcsh:Nutrition. Foods and food supply
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-10 (2021), Nutrition & Metabolism
- Accession number :
- edsair.doi.dedup.....b10b359096e24259e9a0c99aad918dd0