Back to Search
Start Over
Role of adverse pathological features in surgically treated early oral cavity carcinomas with adequate margins and the development of a scoring system to predict local control
- Source :
- Head & Neck. 40:2329-2333
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background The purpose of this study was to determine the factors affecting local control in patients with T1N0 squamous cell carcinoma (SCC) of the tongue. Methods We conducted a retrospective analysis of 144 patients with pT1N0 SCC of the tongue who underwent wide excision and neck dissection without adjuvant therapy. Results The adverse pathological features associated with local control were least margin 5 mm (P = .004), infiltrative margin (P = .403), depth >4 mm (P = .136), lymphovascular invasion (P = .301), and perineural invasion (P = .342). We derived a scoring system of 10 points based on the hazard ratio for local failure; those with scores >5 points had a 5-year local control of Conclusion This study suggests patients having a margin of 5 mm need revision, however, if they do not have additional adverse pathological features (score ≤4), local control is 88% at 5 years, and they may be observed. Those who have margins over 5 mm with a total score >5 may still benefit from adjuvant therapy. Those with margins over 5 mm have improved local control (P = .029).
- Subjects :
- Adult
Male
medicine.medical_specialty
Scoring system
Databases, Factual
Lymphovascular invasion
medicine.medical_treatment
Perineural invasion
India
Risk Assessment
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Tongue
Confidence Intervals
medicine
Adjuvant therapy
Humans
Neoplasm Invasiveness
030223 otorhinolaryngology
Pathological
Aged
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
Aged, 80 and over
Mouth
business.industry
Hazard ratio
Margins of Excision
Neck dissection
Middle Aged
Prognosis
Survival Analysis
Tongue Neoplasms
Early Diagnosis
Treatment Outcome
medicine.anatomical_structure
Otorhinolaryngology
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Female
Radiology
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 10433074
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Head & Neck
- Accession number :
- edsair.doi.dedup.....b0e4819664a43bdff1a52966015a0e0d