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TRPC Channels in the SOCE Scenario
- Source :
- idUS. Depósito de Investigación de la Universidad de Sevilla, instname, Cells, Vol 9, Iss 1, p 126 (2020), idUS: Depósito de Investigación de la Universidad de Sevilla, Universidad de Sevilla (US), Cells
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well known that these channels are activated by stimuli that induce PIP2 hydrolysis. The canonical TRP (TRPC) channels have long been suggested to be constituents of the store-operated Ca2+ (SOC) channels; however, none of the TRPC channels generate Ca2+ currents that resemble ICRAC. STIM1 and Orai1 have been identified as the components of the Ca2+ release-activated Ca2+ (CRAC) channels and there is a body of evidence supporting that STIM1 is able to gate Orai1 and TRPC1 in order to mediate non-selective cation currents named ISOC. STIM1 has been found to interact to and activate Orai1 and TRPC1 by different mechanisms and the involvement of TRPC1 in store-operated Ca2+ entry requires both STIM1 and Orai1. In addition to the participation of TRPC1 in the ISOC currents, TRPC1 and other TRPC proteins might play a relevant role modulating Orai1 channel function. This review summarizes the functional role of TRPC channels in the STIM1–Orai1 scenario. Junta de Extremadura Consejería de Economía e Infraestructura-FEDER Grant IB16046 y GR18061 Junta de Extremadura TA18011 y TA18054 Ministerio de Ciencia, Innovación y Universidades
- Subjects :
- inorganic chemicals
Functional role
Orai1
Cell type
ORAI1 Protein
TRPC1
STIM1
Review
Models, Biological
Biophysical Phenomena
Transient receptor potential channel
store-operated Ca2+ entry (SOCE)
Calcium influx
Animals
Humans
Stromal Interaction Molecule 1
stim1
lcsh:QH301-705.5
TRPC
TRPC Cation Channels
orai1
ORAI1
Chemistry
store-operated ca2+ entry (soce)
General Medicine
Cell biology
trpc1
lcsh:Biology (General)
Calcium Channels
Store-operated Ca2+ entry (SOCE)
calcium influx
Function (biology)
Subjects
Details
- ISSN :
- 20734409
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....b0d04e2d81a9970361c0a9df804070fa