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Inhibiting macrophage PI3Kγ to enhance immunotherapy
- Source :
- Zheng, W & Pollard, J 2016, ' Inhibiting macrophage PI3Kγ to enhance immunotherapy ', Cell Research . https://doi.org/10.1038/cr.2016.132
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- A recent paper published in Nature reports that the immunosuppressive activity of tumor-associated macrophages is regulated via PI3Kγ signaling. Small-molecule inhibitors targeting PI3Kγ stimulate T cell activity against tumor alone and add additional effects for clinically proven PD1 immunotherapy.
Details
- ISSN :
- 17487838 and 10010602
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Cell Research
- Accession number :
- edsair.doi.dedup.....b0cf026021c4b27e47d9d16f4ca0e036