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Synthetic Applications of Intramolecular Thiol-Ene 'Click' Reactions
- Source :
- Molecules, Molecules, Vol 19, Iss 11, Pp 19137-19151 (2014)
- Publication Year :
- 2014
- Publisher :
- MDPI AG, 2014.
-
Abstract
- The intermolecular thiol-ene reaction is emerging as a highly efficient; free-radical mediated “click” process with diverse applications in biofunctionalisation and materials science. The related intramolecular thiol-ene reactions offer significant potential for the preparation of a wide range of sulphur containing heterocycles including synthetic therapeutics such as cyclic peptides and thiosugars. Herein, we review recent advances in intramolecular thiyl-radical mediated reactions and their applications for synthetic and medicinal chemistry.
- Subjects :
- Free Radicals
Pharmaceutical Science
Review
010402 general chemistry
Peptides, Cyclic
01 natural sciences
Analytical Chemistry
Thiosugars
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
Drug Discovery
Organic chemistry
Sulfhydryl Compounds
Physical and Theoretical Chemistry
Ene reaction
free radical
chemistry.chemical_classification
010405 organic chemistry
Organic Chemistry
Intermolecular force
organic synthesis
Combinatorial chemistry
peptide
Cyclic peptide
0104 chemical sciences
chemistry
carbohydrate
Chemistry (miscellaneous)
Intramolecular force
Thiol
Molecular Medicine
Click Chemistry
Organic synthesis
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....b0c3f7cc6131c11496904006e117cc99