Back to Search
Start Over
Effect of Probiotics on Serum Bile Acids in Patients with Ulcerative Colitis
- Source :
- Hepatogastroenterology.
- Publication Year :
- 2011
- Publisher :
- Update Medical Publishing, 2011.
-
Abstract
- Background/aims Evaluation of bile acids (BA) is useful for assessing the changes of intestinal flora in patients with ulcerative colitis (UC). During enterohepatic circulation, the intestinal micro flora cause 7 alpha-dehydroxylation of cholic acid (CA) and chenodeoxycholic acid (CDCA), yielding deoxycholic acid(DCA) and lithocholic acid, respectively. The aim of the present study was to investigate the effects of probiotics in patients with UC by examining changes of the serum BA profile. Methodology Twenty-seven patients were divided into the following 2 groups based on endoscopic findings: Fifteen patients with distal UC (dUC group) and 12 patients with pancolitis (pUC group). After treatment with mesalazine or salazosulfapyridine (5-ASA), all patients achieved remission. Then they were given 5-ASA plus the probiotic Clostridium butyricum Miyairi (3.0 g/day) for 4 weeks. Results After 4 weeks of probiotic treatment, %CDCA was significantly higher and %DCA was significantly lower in the pUC group than in the HV group. In contrast, the dUC group showed no significant differences of %CDCA or %DCA from the HV group after 4 weeks. Conclusions Probiotic therapy restored intestinal flora involved in 7 alpha-dehydroxylation in the dUC group, but not in the pUC group.
- Subjects :
- Adult
Male
Pancolitis
medicine.medical_specialty
Time Factors
Lithocholic acid
Biopsy
Cholic Acid
Chenodeoxycholic Acid
Gastroenterology
Endoscopy, Gastrointestinal
law.invention
Bile Acids and Salts
chemistry.chemical_compound
Probiotic
Gastrointestinal Agents
Japan
Mesalazine
law
Chenodeoxycholic acid
Internal medicine
Humans
Medicine
Enterohepatic circulation
Aged
Hepatology
business.industry
Probiotics
Remission Induction
Deoxycholic acid
Cholic acid
General Medicine
Middle Aged
Intestines
Treatment Outcome
chemistry
Chronic Disease
Clostridium butyricum
Colitis, Ulcerative
Female
Lithocholic Acid
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 01726390
- Database :
- OpenAIRE
- Journal :
- Hepatogastroenterology
- Accession number :
- edsair.doi.dedup.....b0c1fee838252f9237636d8c9ce6111a