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Mitigation mechanisms of Hizikia fusifarme polysaccharide consumption on type 2 diabetes in rats
- Source :
- International Journal of Biological Macromolecules. 164:2659-2670
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- The objective of current work was to explore the potential anti-diabetic mechanisms of Hizikia fusifarme polysaccharide (HFP) in type 2 diabetic rats. The carbohydrate loading experiment illustrated that HFP supplement could reduce blood sugar fluctuations caused by eating through inhibiting the hydrolysis of starch in mice. The analysis of typically diabetic symptoms and serum profiles showed that oral administration of HFP could mitigate hyperglycemia, insulin resistance, dyslipidemia, chronic inflammation and oxidative stress in rats. The 16s rRNA gene sequencing analysis indicated that HFP treatment could restore beneficial composition of gut flora in diabetic rats, and the correlation analysis revealed that the improvement of diabetes is closely related to the modification of gut flora by HFP intervention. Furthermore, the RT-qPCR and western blotting analysis clarified that HFP administration could increase glycogen storage in liver and skeletal muscle of diabetic rats through activating IRS/PI3K/AKT/GLUT signaling pathway and restrain gluconeogenesis via affecting the relative expression of Egr-1 and PEPCK genes.
- Subjects :
- DNA, Bacterial
Male
medicine.medical_specialty
Administration, Oral
Blood sugar
02 engineering and technology
Type 2 diabetes
medicine.disease_cause
DNA, Ribosomal
Biochemistry
Diabetes Mellitus, Experimental
Mice
03 medical and health sciences
chemistry.chemical_compound
Insulin resistance
Polysaccharides
Structural Biology
RNA, Ribosomal, 16S
Internal medicine
Diabetes mellitus
medicine
Animals
Hypoglycemic Agents
Carbohydrate loading
Molecular Biology
030304 developmental biology
0303 health sciences
Bacteria
Glycogen
Sargassum
General Medicine
021001 nanoscience & nanotechnology
medicine.disease
Gastrointestinal Microbiome
Rats
Oxidative Stress
Endocrinology
Diabetes Mellitus, Type 2
Gluconeogenesis
chemistry
0210 nano-technology
Oxidative stress
Subjects
Details
- ISSN :
- 01418130
- Volume :
- 164
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....b0bcc66c45cc1512e19e72e25dcf3786