Back to Search
Start Over
Microglial Activation Induces Generation of Oligodendrocyte Progenitor Cells from the Subventricular Zone after Focal Demyelination in the Corpus Callosum
- Source :
- Developmental Neuroscience. 40:54-63
- Publication Year :
- 2018
- Publisher :
- S. Karger AG, 2018.
-
Abstract
- Neuroblasts derived from neural stem cells (NSCs) in the subventricular zone (SVZ) migrate along the rostral migratory stream into the olfactory bulb to generate interneurons under normal physiological conditions. When demyelination occurs, NSCs or neural progenitor cells (NPCs) in the SVZ provide newly formed oligodendrocytes to demyelinated lesions. The plasticity of NSC/NPC lineages may tend to oligodendrogenesis under the influence of demyelinated lesions. The mechanisms, however, still remain unknown. This study revealed that focal demyelination in the corpus callosum caused activation of the microglia, not only at the site of demyelination but also in the SVZ, and dramatically increased the generation of oligodendrocyte progenitor cells (OPCs) in the SVZ. Furthermore, the inhibition of microglial activation by minocycline treatment decreased OPC generation in the SVZ, suggesting that microglial activation in the SVZ, induced by the focal demyelination in the corpus callosum, regulates NSC/NPC lineage plasticity in situ. In contrast to the findings regarding demyelination in the corpus callosum, inducing focal demyelination in the internal capsule did not induce either microglial activation or OPC generation in the SVZ. These results suggest that the mechanism of OPC generation in the SVZ after inducing demyelinating lesions could be different across the demyelinated regions.
- Subjects :
- Male
0301 basic medicine
Internal capsule
Rostral migratory stream
animal diseases
Subventricular zone
Biology
Corpus callosum
Corpus Callosum
Mice
03 medical and health sciences
0302 clinical medicine
Developmental Neuroscience
Neuroblast
Lateral Ventricles
medicine
Animals
Cell Lineage
Oligodendrocyte Precursor Cells
Mice, Inbred ICR
Microglia
Cell Differentiation
Neural stem cell
Olfactory bulb
Oligodendroglia
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
nervous system
Neurology
Neuroscience
030217 neurology & neurosurgery
Demyelinating Diseases
Subjects
Details
- ISSN :
- 14219859 and 03785866
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Developmental Neuroscience
- Accession number :
- edsair.doi.dedup.....b0b71c895ca78636f63aeeb19efc5bf9