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Reassessing the embryonic origin and potential of craniofacial ectomesenchyme

Authors :
Peter Fabian
J. Gage Crump
Source :
Seminars in Cell & Developmental Biology. 138:45-53
Publication Year :
2023
Publisher :
Elsevier BV, 2023.

Abstract

Of all the cell types arising from the neural crest, ectomesenchyme is likely the most unusual. In contrast to the neuroglial cells generated by neural crest throughout the embryo, consistent with its ectodermal origin, cranial neural crest-derived cells (CNCCs) generate many connective tissue and skeletal cell types in common with mesoderm. Whether this ectoderm-derived mesenchyme (ectomesenchyme) potential reflects a distinct developmental origin from other CNCC lineages, and/or epigenetic reprogramming of the ectoderm, remains debated. Whereas decades of lineage tracing studies have defined the potential of CNCC ectomesenchyme, these are being revisited by modern genetic techniques. Recent work is also shedding light on the extent to which intrinsic and extrinsic cues determine ectomesenchyme potential, and whether maintenance or reacquisition of CNCC multipotency influences craniofacial repair.

Details

ISSN :
10849521
Volume :
138
Database :
OpenAIRE
Journal :
Seminars in Cell & Developmental Biology
Accession number :
edsair.doi.dedup.....b0b6a1b2e32441be80affcfd51b37f93
Full Text :
https://doi.org/10.1016/j.semcdb.2022.03.018