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Group I Metabotropic Glutamate Receptor-mediated Gene Expression in Striatal Neurons
- Source :
- Neurochemical Research. 33:1920-1924
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- Group I mGluRs (mGluR1/5) are G-protein-coupled receptors and are abundantly expressed in most of medium spiny projection neurons in the striatum. Recent evidence demonstrates that group I mGluRs are among essential regulators for constitutive and inducible gene expression in host neurons. Upon activation, mGluR1/5 signals activate extracellular signal-regulated kinases (ERKs) which in turn phosphorylate transcription factors such as cAMP response element-binding protein (CREB) and Elk-1, and thereby facilitate immediate early gene and opioid peptide gene expression. The conventional mGluR1/5 signaling cascade (phosphoinositide hydrolysis and intracellular Ca(2+) release) participates in linking mGluR1/5 to ERK. Additionally, the prominent mGluR1/5 adaptor protein Homer contributes to assemble an efficient signaling apparatus connecting mGluR1/5 to gene expression. The mGluR1/5 linkage to transcription also functions in dopamine-stimulated gene expression. Together, the mGluR1/5-mediated gene expression constitutes a transcription-dependent mechanism underlying molecular adaptations and plasticity related to the pathogenesis of various mental illnesses.
- Subjects :
- MAPK/ERK pathway
Dopamine
Biology
Receptors, Metabotropic Glutamate
CREB
Medium spiny neuron
Biochemistry
Immediate-Early Proteins
Methoxyhydroxyphenylglycol
Cellular and Molecular Neuroscience
Homer Scaffolding Proteins
Gene expression
Animals
Calcium Signaling
Extracellular Signal-Regulated MAP Kinases
Transcription factor
Neurons
Signal transducing adaptor protein
General Medicine
Molecular biology
Corpus Striatum
Cell biology
Gene Expression Regulation
biology.protein
Metabotropic glutamate receptor 1
Mitogen-Activated Protein Kinases
Carrier Proteins
Immediate early gene
Transcription Factors
Subjects
Details
- ISSN :
- 15736903 and 03643190
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Neurochemical Research
- Accession number :
- edsair.doi.dedup.....b0b2b0c5db1602ffc70bee63ec604517