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Metabolomic changes in autopsy-confirmed Alzheimer's disease
- Source :
- Alzheimer'sdementia : the journal of the Alzheimer's Association. 7(3)
- Publication Year :
- 2009
-
Abstract
- Background Metabolomics, the global science of biochemistry, provides powerful tools to map perturbations in the metabolic network and enables simultaneous quantification of several metabolites to identify metabolic perturbances that might provide insights into disease. Methods In this pilot study, we took a targeted electrochemistry-based metabolomics approach where liquid chromatography followed by coulometric array detection enables quantification of over 30 metabolites within key neurotransmitter pathways (dopamine and serotonin) and pathways involved in oxidative stress. Results Using samples from postmortem ventricular cerebrospinal fluid (15 Alzheimer's disease [AD] and 15 nondemented subjects with autopsy-confirmed diagnoses) and by using regression models, correlations, Wilcoxon rank-sum tests, and t -tests we identified alterations in tyrosine, tryptophan, purine, and tocopherol pathways in patients with AD. Reductions in norepinephrine and its related metabolites were also seen, consistent with previously published data. Conclusions These data support further investigation of metabolomics in larger samples of clinical AD as well as in those with preclinical disease for use as biomarkers.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Biogenic Amines
Epidemiology
Metabolic network
Tocopherols
Pilot Projects
Disease
Biology
Bioinformatics
medicine.disease_cause
Article
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Norepinephrine
Metabolomics
Developmental Neuroscience
Dopamine
Alzheimer Disease
Predictive Value of Tests
medicine
Humans
Neurotransmitter
Aged
Aged, 80 and over
Health Policy
Electrochemical Techniques
medicine.disease
Psychiatry and Mental health
Oxidative Stress
chemistry
Purines
Female
Neurology (clinical)
Autopsy
Geriatrics and Gerontology
Alzheimer's disease
Oxidative stress
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 15525279
- Volume :
- 7
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Alzheimer'sdementia : the journal of the Alzheimer's Association
- Accession number :
- edsair.doi.dedup.....b0b29eb8f793b685132147118374cae5