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Automated labelling of cancer textures in colorectal histopathology slides using quasi-supervised learning
- Publication Year :
- 2013
- Publisher :
- Elsevier, 2013.
-
Abstract
- Quasi-supervised learning is a statistical learning algorithm that contrasts two datasets by computing estimate for the posterior probability of each sample in either dataset. This method has not been applied to histopathological images before. The purpose of this study is to evaluate the performance of the method to identify colorectal tissues with or without adenocarcinoma. Light microscopic digital images from histopathological sections were obtained from 30 colorectal radical surgery materials including adenocarcinoma and non-neoplastic regions. The texture features were extracted by using local histograms and co-occurrence matrices. The quasi-supervised learning algorithm operates on two datasets, one containing samples of normal tissues labelled only indirectly, and the other containing an unlabeled collection of samples of both normal and cancer tissues. As such, the algorithm eliminates the need for manually labelled samples of normal and cancer tissues for conventional supervised learning and significantly reduces the expert intervention. Several texture feature vector datasets corresponding to different extraction parameters were tested within the proposed framework. The Independent Component Analysis dimensionality reduction approach was also identified as the one improving the labelling performance evaluated in this series. In this series, the proposed method was applied to the dataset of 22,080 vectors with reduced dimensionality 119 from 132. Regions containing cancer tissue could be identified accurately having false and true positive rates up to 19% and 88% respectively without using manually labelled ground-truth datasets in a quasi-supervised strategy. The resulting labelling performances were compared to that of a conventional powerful supervised classifier using manually labelled ground-truth data. The supervised classifier results were calculated as 3.5% and 95% for the same case. The results in this series in comparison with the benchmark classifier, suggest that quasi-supervised image texture labelling may be a useful method in the analysis and classification of pathological slides but further study is required to improve the results.<br />European Commission (PIRG03-GA-2008-230903)
- Subjects :
- Male
Texture classification
Computer science
Posterior probability
General Physics and Astronomy
Histopathology
02 engineering and technology
Adenocarcinoma
030218 nuclear medicine & medical imaging
Pattern Recognition, Automated
03 medical and health sciences
Digital image
0302 clinical medicine
Image texture
Structural Biology
Artificial Intelligence
Histogram
Image Interpretation, Computer-Assisted
0202 electrical engineering, electronic engineering, information engineering
Humans
General Materials Science
business.industry
Dimensionality reduction
Supervised learning
Pattern recognition
Cell Biology
Independent component analysis
Statistical learning
3. Good health
020201 artificial intelligence & image processing
Female
Artificial intelligence
business
Colorectal Neoplasms
Classifier (UML)
Quasi-supervised learning
Algorithms
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b0ace69ee229d006ffad0ad0731c1176