Back to Search
Start Over
Fas and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Are Closely Linked to the Levels of Glycated and Fetal Hemoglobin in Patients with Diabetes Mellitus
- Source :
- Clinical laboratory. 64(5)
- Publication Year :
- 2018
-
Abstract
- The aim of this study was to investigate the relationships between apoptotic markers and the levels of glycated and fetal hemoglobin (HbA1c and HbF) in diabetes.The levels of Fas, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), HbF, and HbA1c were measured in 112 patients with type 2 diabetes.Diabetic patients with microalbuminuria had an elevated Fas level and a decreased TRAIL level, compared to healthy controls. Elevated HbF level was more often observed in patients with decreased TRAIL level than in those with increased TRAIL level (33.9% versus 12.5%, p0.05). Fas was positively correlated with HbA1c (r = 0.31, p0.001), but TRAIL was inversely correlated with HbA1c and HbF (r = -0.30 and r = -0.32, respectively; p0.001). In a multivariate logistic regression analysis, decreased TRAIL level was significantly associated with enhanced HbF production after adjusting for potential confounders [odds ratio, 1.35 (95% CI, 1.09 - 2.87), p = 0.004]. The diagnostic ability of TRAIL to identify an elevated HbF1.0% was significantly higher than that of the Fas [0.760 (95% CI, 0.638 - 0.882) versus 0.589 (95% CI, 0.457 - 0.721), p0.001].Fas is closely associated with long-term hyperglycemia, while TRAIL plays certain roles in enhancing HbF production in type 2 diabetes.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Apoptosis
Type 2 diabetes
General Biochemistry, Genetics and Molecular Biology
TNF-Related Apoptosis-Inducing Ligand
03 medical and health sciences
Diabetes mellitus
Internal medicine
Fetal hemoglobin
medicine
Albuminuria
Humans
In patient
fas Receptor
Fetal Hemoglobin
Aged
Glycated Hemoglobin
business.industry
Middle Aged
Ligand (biochemistry)
medicine.disease
030104 developmental biology
Endocrinology
Diabetes Mellitus, Type 2
ROC Curve
Microalbuminuria
Tumor necrosis factor alpha
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 14336510
- Volume :
- 64
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical laboratory
- Accession number :
- edsair.doi.dedup.....b0aacece8f8e82282130448db81cf14a