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Alcohol, smoking, and risk of<scp>H</scp>er2‐overexpressing and triple‐negative breast cancer relative to estrogen receptor‐positive breast cancer
- Source :
- International Journal of Cancer. 143:1849-1857
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Epidemiological evidence is limited on how alcohol consumption and smoking are associated with risk of different subtypes of breast cancer, such as triple-negative (TN) and human epidermal growth factor receptor 2-overexpressing (H2E) breast cancers, which may have different etiologies from more common luminal (estrogen receptor [ER+]) breast cancers. In this population-based case-case study, we evaluated the association between alcohol, smoking, and risk of H2E and TN breast cancer, compared with ER+ breast cancers, among women aged 20-69 years. Using polytomous regression, associations between alcohol consumption, smoking, and breast cancer risk were evaluated in 909 ER+, 1,290 TN, and 489 H2E breast cancer patients, with ER+ breast cancer patients as the reference group. Current alcohol consumption at diagnosis was associated with a lower risk of H2E breast cancer (odds ratio = 0.74, 95% confidence interval: 0.58-0.92) relative to ER+ cancers. No difference in association was observed by menopausal status. No association between alcohol consumption and TN breast cancer relative to ER+ breast cancer was observed. Women who smoked did not have an altered risk of TN or H2E breast cancer, relative to ER+ cancer. Our results suggest that alcohol is associated with lower risk of H2E breast cancer relative to ER+ breast cancer. This study adds to the body of epidemiologic evidence that breast cancer etiology differs by breast cancer subtype.
- Subjects :
- Adult
Risk
Oncology
Cancer Research
medicine.medical_specialty
Alcohol Drinking
Receptor, ErbB-2
Population
Estrogen receptor
Triple Negative Breast Neoplasms
Lower risk
Article
Young Adult
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Odds Ratio
Tobacco Smoking
medicine
Humans
030212 general & internal medicine
skin and connective tissue diseases
education
Triple-negative breast cancer
Aged
education.field_of_study
Ethanol
business.industry
Smoking
Cancer
Odds ratio
Middle Aged
medicine.disease
Receptors, Estrogen
030220 oncology & carcinogenesis
Female
Receptors, Progesterone
business
Subjects
Details
- ISSN :
- 10970215 and 00207136
- Volume :
- 143
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi.dedup.....b09e496a98a5af1ba496c1bcc80be9e7
- Full Text :
- https://doi.org/10.1002/ijc.31575