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Lysis Onset Time as Diagnostic Rotational Thromboelastometry Parameter for Fast Detection of Hyperfibrinolysis
- Source :
- Dekker, S E, Viersen, V A, Duvekot, A, de Jong, M, van den Brom, C E, van de Ven, P M, Schober, P & Boer, C 2014, ' Lysis Onset Time as Diagnostic Rotational Thromboelastometry Parameter for Fast Detection of Hyperfibrinolysis ', Anesthesiology, vol. 121, no. 1, pp. 89-97 . https://doi.org/10.1097/ALN.0000000000000229, Anesthesiology, 121(1), 89-97. Lippincott Williams and Wilkins
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- Background: Rotational thromboelastometry is increasingly used to detect hyperfibrinolysis, which is a predictor of unfavorable outcome in patients with coagulation disturbances. In an in vitro study, the authors investigated which thromboelastometric hemostatic parameters could be valuable for fast diagnosis of the severity of hyperfibrinolysis and confirmed their findings in a patient population with hyperfibrinolysis. Methods: Thromboelastometry was performed after adding increasing concentrations of tissue plasminogen activator (0 to 400 ng/ml) to citrated blood samples of 15 healthy volunteers. Lysis parameters included the clotting time, maximum clot firmness, maximum lysis, and lysis onset time (LOT). The relation of tissue plasminogen activator with the LOT was further investigated in a patient population with out-of-hospital cardiac arrest and hyperfibrinolysis. Results: The LOT showed a dose-dependent association with increasing tissue plasminogen activator concentrations. Late, intermediate, or fulminant hyperfibrinolysis was associated with an average LOT (mean ± SD) of 42.7 ± 13.8, 23.2 ± 8.2, and 17.5 ± 4.6 min in the in vitro study and estimated 42.2 ± 8.3, 29.1 ± 1.2, and 14.6 ± 7.7 min in patients, respectively. The authors found a moderately negative correlation between patient plasma tissue plasminogen activator levels and the LOT (r = −0.67; P = 0.01). Conclusion: This study shows that the LOT may be used for fast detection of severe hyperfibrinolysis, with a better resolution than the maximum lysis, and should be further evaluated for optimization of therapeutic strategies in patients with severe clot breakdown.
- Subjects :
- Adult
Male
medicine.medical_specialty
Platelet Aggregation
medicine.medical_treatment
Fulminant
Tissue plasminogen activator
Young Adult
Blood Circulation Time
Reference Values
Internal medicine
Fibrinolysis
medicine
Humans
Prospective Studies
Aged
Dose-Response Relationship, Drug
business.industry
Middle Aged
medicine.disease
Hyperfibrinolysis
Cardiopulmonary Resuscitation
Heart Arrest
Thrombelastography
Thromboelastometry
Treatment Outcome
Anesthesiology and Pain Medicine
Clotting time
Coagulation
Tissue Plasminogen Activator
Anesthesia
Cardiology
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 00033022
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- Anesthesiology
- Accession number :
- edsair.doi.dedup.....b09c02d69340754f97e1fa212e4ab9b6