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Subtle Motor Signs as a Biomarker for Mindful Movement Intervention in Children with Attention-Deficit/Hyperactivity Disorder
- Source :
- J Dev Behav Pediatr
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Objective Previous studies of Tai Chi or mindfulness-based interventions in attention-deficit/hyperactivity disorder (ADHD) have relied on self- or parent-reported outcome measures; however, there is a critical need for the validation of objective biomarkers of treatment. Therefore, we implemented a mindful movement intervention for children with ADHD, hypothesizing that an ADHD-relevant motor control measure could serve as a predictive biomarker of treatment-related improvement. Methods Thirty-four participants were included, 8 to 12 year olds diagnosed with DSM-5 ADHD. Participants engaged in the mindful movement treatment, an 8-week program with 2 classes a week for 60 minutes. At pre- and post-treatment, ADHD symptoms and associated impairment and motor control via the Physical and Neurological Examination for Subtle Signs (PANESS) were assessed. Results The results showed a significant reduction for PANESS Gaits and Station (p ≤ 0.001), total overflow (p = 0.009), and total score (p = 0.001) after treatment, with the largest effect for Gaits and Stations. The results also showed a significant reduction in symptoms of inattention (p ≤ 0.001), hyperactivity/impulsivity (p ≤ 0.001), oppositional defiant disorder (p = 0.001), and executive dysfunction (p ≤ 0.001). There were significant positive correlations between change in PANESS Gaits and Stations and change in both inattentive (p = 0.02) and hyperactive/impulsive symptoms (p = 0.02). There was also a significant positive correlation between change in the PANESS total score and change in inattentive (p = 0.007) and hyperactive/impulsive symptoms (p = 0.042). The change in the PANESS total score (β = 0.295, p = 0.002) predicted post-treatment ADHD severity above the change in inattentive or hyperactive/impulsive symptoms. Conclusion The results suggest the effectiveness of a mindful movement treatment on ADHD symptoms and suggest the PANESS as a candidate motor biomarker for future mindful movement trials. Clinical trial registration ClinicalTrials.gov, NCT02234557, https://clinicaltrials.gov/ct2/show/NCT02234557.
- Subjects :
- Male
Mindfulness
Psychological intervention
Neurological examination
Walking
Impulsivity
Severity of Illness Index
Article
mental disorders
Outcome Assessment, Health Care
Developmental and Educational Psychology
medicine
Humans
Attention deficit hyperactivity disorder
Child
Postural Balance
medicine.diagnostic_test
business.industry
Motor control
medicine.disease
Psychiatry and Mental health
Attention Deficit Disorder with Hyperactivity
Pediatrics, Perinatology and Child Health
Exercise Movement Techniques
Biomarker (medicine)
Female
medicine.symptom
business
Biomarkers
Clinical psychology
Executive dysfunction
Subjects
Details
- ISSN :
- 0196206X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Developmental & Behavioral Pediatrics
- Accession number :
- edsair.doi.dedup.....b09a0e720a5ee9a87a207c732f08fbf6