A case of Schilder's Diffuse Sclerosis diagnosed clinically schizophrenia

A case of Schilder's Diffuse Sclerosis diagnosed clinically as schizophrenia is reported. Asymmetrical diffuse demyelination of the white substance of the frontal lobes and patchy demyelination, more or less sharply delineated, in the brain stem was found. The suggestion is that the clinical course of the diffuse sclerosis with almost exclusively psychiatric symptoms is closely related to the predominant frontal localisation of the neuropathological process.