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A Major Response to Trabectedin in Metastatic Malignant Fibrous Histiocytoma of the Vertebra: A Case Report and Review of the Literature
- Source :
- Tumori Journal. 99:e43-e48
- Publication Year :
- 2013
- Publisher :
- SAGE Publications, 2013.
-
Abstract
- Malignant fibrous histiocytoma is an aggressive tumor, the most common soft-tissue sarcoma of adult age. It is usually located in the extremities and retroperitoneum, and very rarely there is skeletal involvement. Surgery is the preferred treatment in early disease; in advanced disease, chemotherapy is the main therapeutic strategy. We present a 25-year-old female patient diagnosed with a vertebral mass in T5 with a severely compromised spinal cord. She underwent surgical decompression and the pathological findings were consistent with malignant fibrous histiocytoma. After several surgical treatments she had pulmonary progression and was therefore started on chemotherapy. She had a very poor response to most of the administered regimens until she initiated trabectedin 1 mg/m2 every three weeks. She showed a significant improvement with a major response of the lung metastases. This report indicates that trabectedin is an active drug in advanced, previously treated metastatic malignant fibrous histiocytoma.
- Subjects :
- Adult
030222 orthopedics
Cancer Research
Lung Neoplasms
Spinal Neoplasms
Dioxoles
Histiocytoma, Malignant Fibrous
General Medicine
Immunohistochemistry
Magnetic Resonance Imaging
Drug Administration Schedule
Thoracic Vertebrae
03 medical and health sciences
0302 clinical medicine
Oncology
Tetrahydroisoquinolines
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Humans
Female
Tomography, X-Ray Computed
Antineoplastic Agents, Alkylating
030217 neurology & neurosurgery
Trabectedin
Subjects
Details
- ISSN :
- 20382529 and 03008916
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Tumori Journal
- Accession number :
- edsair.doi.dedup.....b08db77d259f170fad4796984081ef15
- Full Text :
- https://doi.org/10.1177/030089161309900227