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Correction: Corrigendum: Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations
- Source :
- Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Medullary thyroid cancer (MTC) can be caused by germline mutations of the RET proto-oncogene or occurs as a sporadic form. It is well known that RET mutations affecting the cysteine-rich region of the protein (MEN2A-like mutations) are correlated with different phenotypes than those in the kinase domain (MEN2B-like mutations). Our aim was to analyse the whole-gene expression profile of MTC with regard to the type of RET gene mutation and the cancer genetic background (hereditary vs sporadic). We studied 86 MTC samples. We demonstrated that there were no distinct differences in the gene expression profiles of hereditary and sporadic MTCs. This suggests a homogeneous nature of MTC. We also noticed that the site of the RET gene mutation slightly influenced the gene expression profile of MTC. We found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer). This study suggests that these genes are significantly deregulated in tumours with MEN2A-like and MEN2B-like mutations; however, further investigations are necessary to demonstrate any clinical impact of these findings.
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Ret gene
endocrine system diseases
Nerve Tissue Proteins
Proto-Oncogene Mas
Article
Transcriptome
03 medical and health sciences
Discoidin Domain Receptor 2
Internal medicine
medicine
Humans
Thyroid Neoplasms
Aged
Multidisciplinary
business.industry
Gene Expression Profiling
Proto-Oncogene Proteins c-ret
Membrane Proteins
Cancer
Medullary thyroid cancer
Middle Aged
Endocrine oncology
medicine.disease
Corrigenda
Carcinoma, Neuroendocrine
030104 developmental biology
Mutation
Dual-Specificity Phosphatases
Female
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....b08c7b9fc63ac2857ed2e0069189d720