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Changes in hemodynamics, renal blood flow and urine output during continuous renal replacement therapies
- Source :
- Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Continuous renal replacement therapies (CRRT) affect hemodynamics and urine output. Some theories suggest a reduced renal blood flow as the cause of the decreased urine output, but the exact mechanisms remain unclear. A prospective experimental study was carried out in 32 piglets (2–3 months old) in order to compare the impact of CRRT on hemodynamics, renal perfusion, urine output and renal function in healthy animals and in those with non-oliguric acute kidney injury (AKI). CRRT was started according to our clinical protocol, with an initial blood flow of 20 ml/min, with 10 ml/min increases every minute until a goal flow of 5 ml/kg/min. Heart rate, blood pressure, central venous pressure, cardiac output, renal blood flow and urine output were registered at baseline and during the first 6 h of CRRT. Blood and urine samples were drawn at baseline and after 2 and 6 h of therapy. Blood pressure, cardiac index and urine output significantly decreased after starting CRRT in all piglets. Renal blood flow, however, steadily increased throughout the study. Cisplatin piglets had lower cardiac index, higher vascular resistance, lower renal blood flow and lower urine output than control piglets. Plasma levels of ADH and urine levels of aquaporin-2 were lower, whereas kidney injury biomarkers were higher in the cisplatin group of piglets. According to our findings, a reduced renal blood flow doesn’t seem to be the cause of the decrease in urine output after starting CRRT.
- Subjects :
- Male
Continuous renal replacement therapy
medicine.medical_specialty
Swine
030232 urology & nephrology
Urology
Renal function
Hemodynamics
Blood Pressure
030204 cardiovascular system & hematology
Decreased urine output
Article
Renal Circulation
03 medical and health sciences
0302 clinical medicine
Animals
Humans
Medicine
Prospective Studies
Child
Multidisciplinary
Renal circulation
business.industry
Acute kidney injury
Blood flow
Acute Kidney Injury
medicine.disease
Disease Models, Animal
Urodynamics
medicine.anatomical_structure
Renal blood flow
Vascular resistance
Swine, Miniature
Female
Vascular Resistance
business
Biomarkers
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....b08b844e56922e42226dffa257acd660