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Long-Term Effectiveness and Safety of Dexmethylphenidate Extended-Release Capsules in Adult ADHD
- Source :
- Journal of Attention Disorders. 12:449-459
- Publication Year :
- 2009
- Publisher :
- SAGE Publications, 2009.
-
Abstract
- Objective: This study evaluates dexmethylphenidate extended release (d-MPH-ER) in adults with ADHD. Method: Following a 5-week, randomized, controlled, fixed-dose study of d-MPH-ER 20 to 40 mg/d, 170 adults entered a 6-month open-label extension (OLE) to assess long-term safety, with flexible dosing of 20 to 40 mg/d. Exploratory effectiveness outcomes included change from Week 5 on ADHD Rating Scale (ADHD-RS) and proportion of responders on Clinical Global Impressions—Improvement (CGI-I) scale. Results: 103 patients completed OLE, and effectiveness was evaluable in 102 patients. d-MPH-ER was well tolerated; the most common adverse events (>15%) were headache, insomnia, and decreased appetite. Mean improvements in ADHD-RS score were −10.2 for patients switched from placebo to d-MPH-ER ( n = 20) and −8.4 for those maintained on d-MPH-ER ( n = 82). Respective CGI-I responder rates were 95.0% and 95.1%. Conclusion: Once-daily d-MPH-ER 20 to 40 mg is safe and effective for long-term treatment of adult ADHD. (J. of Att. Dis. 2009; 12(5) 449-459)
- Subjects :
- Adult
Male
medicine.medical_specialty
Pediatrics
Dexmethylphenidate Hydrochloride
Dexmethylphenidate
Capsules
Personality Assessment
Placebo
law.invention
Young Adult
Double-Blind Method
Randomized controlled trial
Rating scale
law
mental disorders
Developmental and Educational Psychology
medicine
Adverse Drug Reaction Reporting Systems
Humans
Attention deficit hyperactivity disorder
Young adult
Psychiatry
Adverse effect
Dose-Response Relationship, Drug
Middle Aged
medicine.disease
Clinical Psychology
Treatment Outcome
Attention Deficit Disorder with Hyperactivity
Delayed-Action Preparations
Methylphenidate
Central Nervous System Stimulants
Female
Psychology
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 15571246 and 10870547
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Attention Disorders
- Accession number :
- edsair.doi.dedup.....b087c2aabf2aef21415d2c4809b5de7e