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The modus operandi of hydrogen sulfide(H2s)-dependent protein persulfidation in higher plants
- Source :
- Antioxidants, Vol 10, Iss 1686, p 1686 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Protein persulfidation is a post-translational modification (PTM) mediated by hydrogen sulfide (H S), which affects the thiol group of cysteine residues from target proteins and can have a positive, negative or zero impact on protein function. Due to advances in proteomic techniques, the number of potential protein targets identified in higher plants, which are affected by this PTM, has increased considerably. However, its precise impact on biological function needs to be evaluated at the experimental level in purified proteins in order to identify the specific cysteine(s) residue(s) affected. It also needs to be evaluated at the cellular redox level given the potential interactions among different oxidative post-translational modifications (oxiPTMs), such as S-nitrosation, glutathionylation, sulfenylation, S-cyanylation and S-acylation, which also affect thiol groups. This review aims to provide an updated and comprehensive overview of the important physiological role exerted by persulfidation in higher plants, which acts as a cellular mechanism of protein protection against irreversible oxidation.<br />F.J.C. and J.M.P. research is supported by a European Regional Development Fund cofinanced grant from the Spanish Ministry of Science, Innovation and Universities (PID2019-103924GBI00), the Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020) (P18-FR-1359) and Junta de Andalucía (group BIO192), Spain.
- Subjects :
- chemistry.chemical_classification
Protein function
Hydrogen sulfide
Physiology
Clinical Biochemistry
Cell Biology
Oxidative phosphorylation
RM1-950
Biochemistry
Thiol group
Cellular mechanism
S-desulfurization
Oxidative posttranslational modifications
Residue (chemistry)
chemistry.chemical_compound
chemistry
Thiol
Persulfidation
Therapeutics. Pharmacology
Molecular Biology
Cysteine
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Antioxidants, Vol 10, Iss 1686, p 1686 (2021)
- Accession number :
- edsair.doi.dedup.....b059c38f1c5bb4610c9bfa39b9d98d2f