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Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review
- Source :
- Nutrients, Vol 11, Iss 2, p 380 (2019), Nutrients
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Celiac disease (CD) is an immune-mediated gastrointestinal disorder driven by innate and adaptive immune responses to gluten. Patients with CD are at an increased risk of several neurological manifestations, frequently peripheral neuropathy and gluten ataxia. A systematic literature review of the most commonly reported neurological manifestations (neuropathy and ataxia) associated with CD was performed. MEDLINE, Embase, the Cochrane Library, and conference proceedings were systematically searched from January 2007 through September 2018. Included studies evaluated patients with CD with at least one neurological manifestation of interest and reported prevalence, and/or incidence, and/or clinical outcomes. Sixteen studies were included describing the risk of gluten neuropathy and/or gluten ataxia in patients with CD. Gluten neuropathy was a neurological manifestation in CD (up to 39%) in 13 studies. Nine studies reported a lower risk and/or prevalence of gluten ataxia with a range of 0%–6%. Adherence to a gluten-free diet appeared to improve symptoms of both neuropathy and ataxia. The prevalence of gluten neuropathy and gluten ataxia in patients with CD varied in reported studies, but the increased risk supports the need for physicians to consider CD in patients with ataxia and neurological manifestations of unknown etiology.
- Subjects :
- medicine.medical_specialty
Ataxia
prevalence
lcsh:TX341-641
Review
Disease
Lower risk
03 medical and health sciences
0302 clinical medicine
gluten-free diet
Central Nervous System Diseases
gluten neuropathy
medicine
Humans
chemistry.chemical_classification
Nutrition and Dietetics
business.industry
Incidence (epidemiology)
nutritional and metabolic diseases
medicine.disease
Dermatology
Gluten
digestive system diseases
Peripheral neuropathy
Gastrointestinal disorder
chemistry
incidence
Etiology
030211 gastroenterology & hepatology
medicine.symptom
business
lcsh:Nutrition. Foods and food supply
celiac disease
030217 neurology & neurosurgery
gluten ataxia
Food Science
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....b05931cae8574abe05154f5b7b8bbf88