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Anti-angiogenic treatment strategies for the therapy of endometriosis
- Source :
- Human Reproduction Update. 18:682-702
- Publication Year :
- 2012
- Publisher :
- Oxford University Press (OUP), 2012.
-
Abstract
- background: Angiogenesis, i.e. the development of new blood vessels from pre-existing ones, represents an integral part in the patho- genesis of endometriosis. During the last decade, an increasing number of studies have therefore focused on the anti-angiogenic treatment of the disease. The present review provides a systematic overview of these studies and critically discusses the future role of anti-angiogenic therapy in the multimodal management of endometriosis. methods: Literature searches were performed in PubMed, MEDLINE and ISI Web of Knowledge for original articles published before the end of March 2012, written in the English language and focusing on anti-angiogenic approaches for the therapy of endometriosis. The searches included both animal and human studies. results: Numerous compounds of different substance groups have been shown to exert anti-angiogenic effects on endometriotic lesions under experimental in vitro and in vivo conditions. These include growth factor inhibitors, endogenous angiogenesis inhibitors, fumagillin analogues, statins, cyclo-oxygenase-2 inhibitors, phytochemical compounds, immunomodulators, dopamine agonists, peroxisome prolifer- ator-activated receptor agonists, progestins, danazol and gonadotropin-releasing hormone (GnRH) agonists. However, clinical evidence for their efficacy in anti-angiogenic endometriosis therapy is still lacking. conclusions: Anti-angiogenic compounds hold great promise for the future treatment of endometriosis because they may inhibit the establishment of new endometriotic lesions in early stages of the disease or after surgical treatment. Further experimental studies, controlled clinical trials in particular, are required now to clarify which compounds fulfil these expectations without inducing severe side effects in patients with endometriosis.
- Subjects :
- Vascular Endothelial Growth Factor A
Pathology
medicine.medical_specialty
Angiogenesis
Peroxisome Proliferator-Activated Receptors
Endometriosis
Angiogenesis Inhibitors
Disease
Bioinformatics
Cyclohexanes
In vivo
Angiostatic Proteins
medicine
Humans
Immunologic Factors
Fumagillin
Danazol
Cyclooxygenase 2 Inhibitors
business.industry
Obstetrics and Gynecology
medicine.disease
Clinical trial
Reproductive Medicine
Dopamine Agonists
Fatty Acids, Unsaturated
Female
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Sesquiterpenes
Phytotherapy
medicine.drug
Hormone
Subjects
Details
- ISSN :
- 14602369 and 13554786
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Human Reproduction Update
- Accession number :
- edsair.doi.dedup.....b05072c6da86605300d1f8e99cba2bd9