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Nucleolar size indicates the rapidity of cell proliferation in cancer tissues
- Source :
- The Journal of Pathology. 191:181-186
- Publication Year :
- 2000
- Publisher :
- Wiley, 2000.
-
Abstract
- In order to define the importance of the nucleolus in tumour pathology, the relationship between nucleolar size and function and tumour mass growth rate was studied in vivo. Ten established human cancer cell lines from colon carcinomas and neuroblastomas were inoculated subcutaneously in athymic mice and the doubling time (DT) of the xenograft tumour mass was calculated. The tumour DTs ranged from 3.2 to 15.7 days. Nucleolar size was evaluated in sections from formalin-fixed and paraffin-embedded tumour samples after silver staining for AgNOR proteins, using a specific image analysis system. The nucleolar area values were inversely related to the xenograft tumour mass DTs (r=-0.90; p
- Subjects :
- Male
Silver Staining
Time Factors
Nucleolus
Mice, Nude
Cell Count
Pathology and Forensic Medicine
Silver stain
Mice
Neuroblastoma
chemistry.chemical_compound
RNA Polymerase I
Proliferating Cell Nuclear Antigen
Tumor Cells, Cultured
medicine
Animals
Humans
Doubling time
biology
Cell growth
Cancer
medicine.disease
Molecular biology
Proliferating cell nuclear antigen
Cell Transformation, Neoplastic
Bromodeoxyuridine
chemistry
Colonic Neoplasms
Cancer cell
biology.protein
Cell Division
Cell Nucleolus
Subjects
Details
- ISSN :
- 10969896 and 00223417
- Volume :
- 191
- Database :
- OpenAIRE
- Journal :
- The Journal of Pathology
- Accession number :
- edsair.doi.dedup.....b04f8bc77683bfbeeec45670fcbade7e