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Chronic Intermittent Hypobaric Hypoxia Enhances Bone Fracture Healing

Authors :
Zhiyong Hou
Kai Bao
Liping Zhang
Jialiang Guo
Li Zhang
Yingze Zhang
Lin Jin
Jinglue Hu
Source :
Frontiers in Endocrinology, Frontiers in Endocrinology, Vol 11 (2021)
Publication Year :
2021
Publisher :
Frontiers Media S.A., 2021.

Abstract

The effect of chronic intermittent hypobaric hypoxia (CIHH) on bone fracture healing is not elucidated. The present study aimed to investigate the role of CIHH on bone fracture healing and the mechanism. The Sprague-Dawley rats were randomly divided into the CIHH group and control group and monitored for 2, 4, or 8 weeks after femoral fracture surgery. Bone healing efficiency was significantly increased in the CIHH group as evidenced by higher high-density bone volume fractions, higher bone mineral density, higher maximum force, and higher stiffness. Histologically, the CIHH group exhibited superior bone formation, endochondral ossification, and angiogenic ability compared with the control group. The expression of HIF-1α and its downstream signaling proteins VEGF, SDF-1/CXCR4 axis were increased by the CIHH treatment. Moreover, the expression of RUNX2, osterix, and type I collagen in the callus tissues were also up-regulated in the CIHH group. In conclusion, our study demonstrated that CIHH treatment improves fracture healing, increases bone mineral density, and increases bone strength via the activation of HIF-1α and bone production-related genes.

Details

Language :
English
ISSN :
16642392
Volume :
11
Database :
OpenAIRE
Journal :
Frontiers in Endocrinology
Accession number :
edsair.doi.dedup.....b04297a369bf79138ac2deef0ead5926