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Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor
- Source :
- Bioorganic & Medicinal Chemistry Letters. 14:251-256
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles.
- Subjects :
- Male
Serine Proteinase Inhibitors
Proline
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Peptide
Hepacivirus
Viral Nonstructural Proteins
Biochemistry
Chemical synthesis
Rats, Sprague-Dawley
Bridged Bicyclo Compounds
In vivo
Drug Discovery
medicine
Animals
Humans
Molecular Biology
ADME
chemistry.chemical_classification
biology
Serine Endopeptidases
Organic Chemistry
Dipeptides
Protease inhibitor (biology)
In vitro
Rats
Enzyme
chemistry
Enzyme inhibitor
biology.protein
Molecular Medicine
medicine.drug
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....b03ae4d6ce258904c379bc3ebcafdec6
- Full Text :
- https://doi.org/10.1016/j.bmcl.2003.09.074