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Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly
- Source :
- Journal of the Renin-Angiotensin-Aldosterone System: JRAAS, Scopus, Repositório Institucional da UNESP, Universidade Estadual Paulista (UNESP), instacron:UNESP, Journal of the Renin-Angiotensin-Aldosterone System, Vol 19 (2018), Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2018
-
Abstract
- Made available in DSpace on 2018-12-11T17:24:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objective: Polymorphisms of the renin angiotensin system (RAS) are associated with increases in blood pressure (BP). Physical exercise has been considered the main strategy to prevent this increase. This study aimed to investigate the relationship between estimated training status (TS), BP and angiotensin-converting enzyme (ACE) activity in elderly people classified as low or high risk to develop hypertension according to genetic profile. Methods: A total of 155 elderly participants performed the following assessments: general functional fitness index (GFFI), systolic BP (SBP) and diastolic BP (DBP), blood collection for ACE activity and analyses of the RAS polymorphisms. Results: Uncontrolled hypertensive (UHT) participants presented higher values of SBP and DBP compared with normotensive (NT) and controlled hypertensive (CHT) participants. No differences were found in ACE activity and GFFI between groups. In the high risk group, UHT presented higher values of SBP and DBP compared with other groups. CHT presented higher values of SBP compared with NT. Furthermore, UHT presented higher values of ACE activity compared with CHT and lower values of GFFI compared with NT. Conclusion: MDA, TIA and TIC genetic combinations were associated with high risk of developing hypertension while the maintenance of good levels of TS was associated with lower BP values and ACE activity. Department of Physical Education São Paulo State University (UNESP) School of Science School of Nursing of Ribeirão Preto USP - University of São Paulo Faculty of Medicine of Ribeirão Preto USP - University of São Paulo Bauru School of D entistry University of São Paulo Department of Physical Education São Paulo State University (UNESP) School of Science FAPESP: Grants no 2015/24847-8 to ASZ.
- Subjects :
- Male
medicine.medical_specialty
Medicine (General)
Genotype
Physical fitness
Physical exercise
030204 cardiovascular system & hematology
Peptidyl-Dipeptidase A
elderly
Renin-Angiotensin System
03 medical and health sciences
0302 clinical medicine
Endocrinology
R5-920
Internal medicine
Renin–angiotensin system
Internal Medicine
medicine
Humans
Ace activity
Alleles
Aged
Polymorphism, Genetic
business.industry
Hemodynamics
blood pressure
030229 sport sciences
Blood pressure
Hypertension
Cardiology
physical fitness
Female
Original Article
business
Polymorphisms
TREINAMENTO FÍSICO
RAS
Subjects
Details
- ISSN :
- 17528976
- Volume :
- 19
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of the renin-angiotensin-aldosterone system : JRAAS
- Accession number :
- edsair.doi.dedup.....b0321a6884aef0044c3af955f648e030