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Earliest pulmonary vein potential‑guided cryoballoon ablation is associated with better clinical outcomes than conventional cryoballoon ablation: A result from two randomized clinical studies
- Source :
- Journal of Cardiovascular Electrophysiology. 32:2933-2942
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- INTRODUCTION With regard to short-term outcome in atrial fibrillation (AF), the benefit of cryoballoon ablation (CBA) by pressing a balloon against the earliest pulmonary vein (PV) potential site during PV isolation (earliest potential [EP]-guided CBA) has been previously demonstrated. The present study aimed to evaluate the long-term outcome of the EP-guided CBA. METHODS AND RESULTS This study included 136 patients from two randomized studies, who underwent CBA for paroxysmal AF for the first time. Patients were randomly assigned to the EP-guided and conventional CBA groups in each study. In the EP-guided CBA group, we pressed a balloon against the EP site when the time-to-isolation (TTI) after cryoapplication exceeded 60 and 45 s in the first and second studies, respectively. We compared the clinical outcomes for 1 year after the procedure between the EP-guided CBA group (68 patients) and the conventional CBA group (68 patients). The primary endpoint was the recurrence of atrial arrhythmia after ablation. No significant differences in baseline characteristics were observed between the two groups. Compared with the conventional CBA group, the EP-guided CBA group had a significantly higher success rate at TTI ≤ 90 s (98.5% vs. 90.0%, p
- Subjects :
- medicine.medical_specialty
business.industry
medicine.medical_treatment
Atrial fibrillation
medicine.disease
Balloon
Ablation
Cryosurgery
Pulmonary vein
Surgery
Treatment Outcome
Pulmonary Veins
Recurrence
Physiology (medical)
Baseline characteristics
Atrial Fibrillation
Catheter Ablation
medicine
Clinical endpoint
Humans
Cardiology and Cardiovascular Medicine
business
Cryoballoon ablation
Randomized Controlled Trials as Topic
Paroxysmal AF
Subjects
Details
- ISSN :
- 15408167 and 10453873
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Electrophysiology
- Accession number :
- edsair.doi.dedup.....b026877b527175979798f0023afb623f