Back to Search
Start Over
Use of Idarucizumab to Revert the Anticoagulant Effect of Dabigatran in Heart Transplant Surgery: An Institutional Experience
Use of Idarucizumab to Revert the Anticoagulant Effect of Dabigatran in Heart Transplant Surgery: An Institutional Experience
- Source :
- Case Reports in Cardiology, Case Reports in Cardiology, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi, 2020.
-
Abstract
- Heart transplant is a surgical procedure with a high risk of perioperative bleeding in patients with a previous history of sternotomy, congestive liver disease, and/or use of oral anticoagulants. Anticoagulation is usually done with coumarin agents (warfarin, acenocoumarol), while on the waiting list, vitamin K is available allowing for partial reversal of the anticoagulant effect, although with variable INR and risk of uncontrolled bleeding. Direct oral anticoagulants have emerged as an alternative to the use of coumarins in patients with nonvalvular atrial fibrillation (NVAF). The main disadvantage of this group of drugs is that there was no specific reversal agent available that would allow an urgent reversal of the anticoagulant effect. The recent commercialization of idarucizumab (specific reversal agent) has allowed patients with NVAF on the waiting list for heart transplant to be treated with dabigatran. We present the case of a patient with advanced chronic heart failure and NVAF anticoagulated with dabigatran, who underwent urgent heart transplant after administration of idarucizumab, without complications derived from its use or from anticoagulation.
- Subjects :
- medicine.medical_specialty
Acenocoumarol
business.industry
Warfarin
Atrial fibrillation
Idarucizumab
Case Report
Perioperative
030204 cardiovascular system & hematology
medicine.disease
Dabigatran
03 medical and health sciences
Liver disease
0302 clinical medicine
Internal medicine
Heart failure
RC666-701
medicine
Cardiology
Diseases of the circulatory (Cardiovascular) system
030212 general & internal medicine
Cardiology and Cardiovascular Medicine
Intensive care medicine
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20906412 and 20906404
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Case Reports in Cardiology
- Accession number :
- edsair.doi.dedup.....b01b448321f3e254c17be7bc6ba07204