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Structure, regulation and function of gap junctions in liver
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2015
- Publisher :
- Informa Healthcare, 2015.
-
Abstract
- Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular communication between cells. They arise from the interaction of two hemichannels of adjacent cells, which in turn are composed of six connexin proteins. In liver, gap junctions are predominantly found in hepatocytes and play critical roles in virtually all phases of the hepatic life cycle, including cell growth, differentiation, liver-specific functionality and cell death. Liver gap junctions are directed through a broad variety of mechanisms ranging from epigenetic control of connexin expression to post-translational regulation of gap junction activity. This paper reviews established and novel aspects regarding the architecture, control and functional relevance of liver gap junctions.
- Subjects :
- 0301 basic medicine
Cell signaling
connexin
Clinical Biochemistry
Connexin
Cell Communication
Biology
liver
Connexins
Article
03 medical and health sciences
0302 clinical medicine
Cell–cell interaction
Animals
Humans
Epigenetics
gap junctions
Cell growth
FÍGADO (CITOLOGIA)
Cell Cycle
Gap junction
Cell Biology
General Medicine
Cell cycle
Cell biology
030104 developmental biology
030220 oncology & carcinogenesis
Hepatocytes
Intracellular
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Accession number :
- edsair.doi.dedup.....b01804a98fc70fdaa5f4c4aad7cabfa3