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The influence of placebo administration on the first- night effect in patients with insomnia disorder
- Source :
- Sleep Medicine. 72:138-143
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- We aimed to investigate the effects of placebo on the first-night effect (FNE) in insomniacs.In sum, 36 patients with insomnia disorder who met the DSM-5 criteria were enrolled in this study. Sixteen patients with insomnia disorder were given two days of placebo intervention (placebo-administration group, PL). Twenty patients with insomnia disorder (drug-free group, DF) were not given any interventions. All participants underwent two consecutive nights of polysomnographic (PSG) testing in the sleep laboratory. Sleep diaries were recorded during one week at home before the PSG nights and on two subsequent nights.The results demonstrated that compared with the DF group, sleep onset latency (SOL), time in bed (TIB) and wake after sleep onset (WASO) significantly increased and sleep efficiency (SE) significantly decreased in the first sleep lab night in the PL group (all p 0.05). Moreover, compared with the second night, significant differences were observed in lower self-reported total sleep time (TST) and more subjective WASO during the first night in the PL group (all p 0.05). However, no significant difference was found in the duration and percentage of N1, N2, N3 and REM between the two groups.In patients with insomnia disorder, placebo administration may increase the occurrence of worse sleep without causing a change in the duration and percentage of N1, N2, N3 and REM on the first sleep lab night. In some cases, a placebo may not serve as treatment but may result in a nocebo effect.
- Subjects :
- medicine.medical_specialty
business.industry
Polysomnography
General Medicine
Placebo
Sleep in non-human animals
Nocebo Effect
03 medical and health sciences
0302 clinical medicine
030228 respiratory system
Time in bed
Sleep Initiation and Maintenance Disorders
Internal medicine
mental disorders
Insomnia
medicine
Humans
In patient
Self Report
Sleep onset latency
medicine.symptom
Sleep onset
Sleep
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13899457
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Sleep Medicine
- Accession number :
- edsair.doi.dedup.....b0178e5b703a93f90cfba9fde059fc89