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A Phage Protein Aids Bacterial Symbionts in Eukaryote Immune Evasion
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname, Cell Host & Microbe, 26 (4). 542-550.e5., Cell Host & Microbe, 26(4), 542. Cell Press
- Publication Year :
- 2019
-
Abstract
- 15 pages, 5 figures, 1 table, supplemental Information https://doi.org/10.1016/j.chom.2019.08.019<br />Phages are increasingly recognized as important members of host-associated microbiomes, with a vast genomic diversity. The new frontier is to understand how phages may affect higher order processes, such as in the context of host-microbe interactions. Here, we use marine sponges as a model to investigate the interplay between phages, bacterial symbionts, and eukaryotic hosts. Using viral metagenomics, we find that sponges, although massively filtering seawater, harbor species-specific and even individually unique viral signatures that are taxonomically distinct from other environments. We further discover a symbiont phage-encoded ankyrin-domain-containing protein, which is widely spread in phages of many host-associated contexts including human. We confirm in macrophage infection assays that the ankyrin protein (ANKp) modulates the eukaryotic host immune response against bacteria. We predict that the role of ANKp in nature is to facilitate coexistence in the tripartite interplay between phages, symbionts, and sponges and possibly many other host-microbe associations<br />We acknowledge funding by the DFG CRC1182 to U.H. (TPB1), T.L. (TPA4), P.R. (TPC2), and A.K. (TPC3). M.T.J. was supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Würzburg, and the Young Investigator Award of CRC1182. S.M.M. was supported by the Studienstiftung des Deutschen Volkes
- Subjects :
- Ankyrins
Viral metagenomics
viromics
viruses
Coronacrisis-Taverne
Context (language use)
Ankyrin
Microbiology
Cell Line
03 medical and health sciences
Mice
0302 clinical medicine
Symbiosis
ankyrin
Virology
phage
Animals
Bacteriophages
Microbiome
Community ecology
innate immunity
030304 developmental biology
immune evasion
Immune Evasion
Genetics
Innate immunity
Marine sponge
0303 health sciences
Innate immune system
biology
Bacteria
Host (biology)
Microbiota
biology.organism_classification
symbiosis
3. Good health
Porifera
Mice, Inbred C57BL
Phage
Parasitology
Eukaryote
Viromics
Female
030217 neurology & neurosurgery
community ecology
marine sponge
Subjects
Details
- ISSN :
- 19346069 and 19313128
- Volume :
- 26
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Cell hostmicrobe
- Accession number :
- edsair.doi.dedup.....b000ce68eb68ef238a1bedffc8188a4b