Additive effect of betaxolol and epinephrine in primary open angle glaucoma

To the Editor. —In our monthly journal club, we discussed with much interest the article by Allen and Epstein. 1 The article provided a much-needed and stimulating discussion of the role of adrenergic agonists and antagonists in the control of intraocular pressure (IOP). On careful review of the data and their portrayal and interpretation, we found a number of discrepancies. First, assuming the values in the "Results" section and Table 1 are correct, two data points are plotted incorrectly in Fig 2. The mean baseline IOP for the timolol group receiving no treatment in Table 1, 28.0 mm Hg, was plotted too low, at 27.5 mm Hg, in Fig 2. Also, the mean IOP at week 4 for the timolol group treated with epinephrine in Table 1, 21.2 mm Hg, was plotted too high, at 21.7 mm Hg, in Fig 2. The plotting errors in Fig 2 are visually additive