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Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48
- Source :
- European Journal of Immunology. 28:4325-4331
- Publication Year :
- 1998
- Publisher :
- Wiley, 1998.
-
Abstract
- The physiological functions of murine CD2 and its ligand CD48 are uncertain. We have examined the role of the CD2-CD48 interaction in murine T cell activation using a series of Chinese hamster ovary (CHO) cell transfectants. CHO cells expressing I-Ad together with CD48 induced more potent activation of OVA-specific, I-Ad -restricted DO11.10-transgenic T cells than CHO cells expressing I-Ad alone. CD48 augmented proliferation and IL-2 production in response to antigen. The enhancing effect of CD48 was of the same magnitude as that seen for CD80 (B7-1). Conjugate assays revealed the ability of CD48 to increase adhesion between T cells and CHO transfectants. The enhancing effects of CD48 on T cell-antigen-presenting cell adhesion and T cell activation were inhibited by anti-CD2 monoclonal antibody. This report provides the first evidence that the CD2 ligand CD48 contributes to the interactions of murine CD4+ T cells with antigen-presenting cells.
- Subjects :
- CD4-Positive T-Lymphocytes
Cytotoxicity, Immunologic
T cell
Immunology
CD2 Antigens
CHO Cells
CD48 Antigen
Biology
Ligands
Lymphocyte Activation
Transfection
Mice
Interleukin 21
Antigens, CD
Cricetinae
medicine
Animals
Immunology and Allergy
Cytotoxic T cell
IL-2 receptor
Antigen-presenting cell
ZAP70
CD28
Molecular biology
Cell biology
medicine.anatomical_structure
CD80
Signal Transduction
Subjects
Details
- ISSN :
- 15214141 and 00142980
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology
- Accession number :
- edsair.doi.dedup.....affde6456f78150c790ddc63641cb92c