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Effect of the antitumor antibiotic chromomycin A3 on the humoral immune response in rats
- Source :
- Infection and Immunity. 12:943-946
- Publication Year :
- 1975
- Publisher :
- American Society for Microbiology, 1975.
-
Abstract
- Chromomycin A3 (250 mug/kg) suppressed the humoral immune response in rats against sheep erythrocytes when administered 48 h or later after antigenic stimulus. The antibiotic at this dose enhanced immunity when given along with or before antigen administration. The natural heterohemagglutinin levels in rabbits and guinea pigs were not affected by the antibiotic (10 mug/kg per day x 7).
- Subjects :
- Male
medicine.medical_specialty
Erythrocytes
Time Factors
medicine.drug_class
Guinea Pigs
Immunology
Antibiotics
Antineoplastic Agents
Biology
Microbiology
Hemolysin Proteins
chemistry.chemical_compound
Immune system
Antigen
Immunity
Internal medicine
medicine
Chromomycins
Animals
Antigens
Microbiology & Cell Biology
Sheep
Rats, Inbred Strains
Rats
Hemagglutinins
Infectious Diseases
Endocrinology
chemistry
Antibody Formation
Female
Parasitology
Chromomycin A3
Rabbits
Injections, Intraperitoneal
Antibody formation
Research Article
Subjects
Details
- ISSN :
- 10985522 and 00199567
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Infection and Immunity
- Accession number :
- edsair.doi.dedup.....affb7007d9d081e61683e44b6b5acbe5