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The saponin-rich fraction of a Gymnema sylvestre R. Br. aqueous leaf extract reduces cafeteria and high-fat diet-induced obesity
- Source :
- Zeitschrift fur Naturforschung. C, Journal of biosciences. 67(1-2)
- Publication Year :
- 2012
-
Abstract
- We examined the antiobesity effect of a saponin-rich fraction of a Gymnema sylvestre R. Br. aqueous leaf extract (SGE) using cafeteria and high-fat diet-induced obese rats for a period of eight weeks. SGE was orally administered at a dose of 100 mg/kg body weight once a day to the treatment group. It significantly decreased the body weight, food consumption, visceral organs weight, and the levels of triglycerides, total cholesterol, low-density lipoproteins, very low-density lipoproteins, atherogenic index, glucose, and increased the levels of high-density lipoproteins. There was no significant difference with respect to all parameters of the study in case of normal (N) diet and N diet + SGE rats. In vitro, SGE inhibited the pancreatic lipase activity. The present study gave clear evidence that the SGE has a significant antiobese action, supporting its use in traditional medicine, and can be used as a substitute for synthetic drugs.
- Subjects :
- Male
medicine.medical_specialty
Saponin
Fraction (chemistry)
Cafeteria
Body weight
General Biochemistry, Genetics and Molecular Biology
High fat diet induced obesity
Internal medicine
Botany
medicine
Animals
Obesity
Rats, Wistar
chemistry.chemical_classification
Aqueous solution
biology
Plant Extracts
Significant difference
Body Weight
Gymnema sylvestre
Feeding Behavior
Organ Size
Saponins
biology.organism_classification
Dietary Fats
Rats
Plant Leaves
Endocrinology
chemistry
Subjects
Details
- ISSN :
- 09395075
- Volume :
- 67
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Zeitschrift fur Naturforschung. C, Journal of biosciences
- Accession number :
- edsair.doi.dedup.....afef970c33efaa7beecffeb4f21115ac