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Reliable femoral chronic total occlusion model using a thin biodegradable polymer coated copper stent in a porcine model
- Source :
- Journal of Materials Science: Materials in Medicine. 26
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Chronic total occlusions (CTOs) are common in patients with peripheral arterial disease (PAD). This study aimed to examine the feasibility and reliability of a CTO induced by a thin biodegradable polymer (polyglycolic acid) coated copper stent in a porcine femoral artery. Novel thin biodegradable polymer coated copper stents (9 mm long) were crimped on an angioplasty balloon (4.5 mm diameter × 12 mm length) and inserted into the femoral artery. Histopathologic analysis was performed 35 days after stenting. In five of six stented femoral arteries, severe in-stent restenosis and total occlusion with collateral circulation were observed without adverse effects such as acute stent thrombosis, leg necrosis, or death at 5 weeks. Fibrous tissue deposition, small vascular channels, calcification, and inflammatory cells were observed in hematoxylin-eosin, Carstair's, and von Kossa tissue stains; these characteristics were similar to pathological findings associated with CTOs in humans. The neointima volume measured by micro-computed tomography was 93.9 ± 4.04 % in the stented femoral arteries. CTOs were reliably induced by novel thin biodegradable polymer coated copper stents in porcine femoral arteries. Successful induction of CTOs may provide a practical understanding of their formation and application of an interventional device for CTO treatment.
- Subjects :
- Neointima
medicine.medical_specialty
Materials science
Swine
medicine.medical_treatment
Biomedical Engineering
Biophysics
Bioengineering
Femoral artery
Biomaterials
Coated Materials, Biocompatible
Restenosis
Blood vessel prosthesis
medicine.artery
Absorbable Implants
medicine
Animals
Von Kossa stain
Graft Occlusion, Vascular
Stent
equipment and supplies
medicine.disease
Collateral circulation
Blood Vessel Prosthesis
Surgery
Femoral Artery
Disease Models, Animal
Stents
Copper
Polyglycolic Acid
Calcification
Subjects
Details
- ISSN :
- 15734838 and 09574530
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Materials Science: Materials in Medicine
- Accession number :
- edsair.doi.dedup.....afe6b9bc12e318d997bf90f0e2fda2e7