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Differential effects of completed and incomplete pregnancies on the risk of Alzheimer disease
- Source :
- Neurology
- Publication Year :
- 2018
-
Abstract
- ObjectiveTo investigate the effects of completed pregnancy with childbirth and incomplete pregnancy without childbirth on the late-life cognition and the risk of Alzheimer disease (AD) in women.MethodsUsing the pooled data of 3,549 women provided by 2 population-based cohort studies, we conducted logistic regression analyses to examine retrospectively the associations of completed and incomplete pregnancy with the risks of mild cognitive impairment and AD. For women without dementia, we also conducted analyses of covariance to examine the associations of completed and incomplete pregnancy with Mini-Mental State Examination (MMSE) score.ResultsGrand multiparous women who experienced ≥5 completed pregnancies showed an ≈1.7-fold higher risk of AD than those who experienced 1 to 4 completed pregnancies (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.04–2.72), while those who had incomplete pregnancies showed half the level of AD risk compared with those who never experienced an incomplete pregnancy (OR 0.43, 95% CI 0.24–0.76 for 1 incomplete pregnancy; OR 0.56, 95% CI 0.34–0.92 for ≥2 incomplete pregnancies). In women without dementia, the grand multiparous had worse MMSE scores than those with 1 to 4 completed pregnancies (p < 0.001), while those who experienced ≥1 incomplete pregnancies had better MMSE scores than those who never experienced an incomplete pregnancy (p = 0.008).ConclusionsGrand multiparity was associated with high risk of AD, while incomplete pregnancy was associated with low risk of AD in late life.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
International Cooperation
Population
Logistic regression
Community Health Planning
Article
Cohort Studies
03 medical and health sciences
Age Distribution
0302 clinical medicine
Alzheimer Disease
Pregnancy
Republic of Korea
medicine
Humans
Dementia
Childbirth
education
Reproductive History
Aged
Aged, 80 and over
Psychiatric Status Rating Scales
education.field_of_study
Obstetrics
business.industry
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Pregnancy Complications
030104 developmental biology
Female
Neurology (clinical)
Cognition Disorders
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....afdb7a64c16596e32589bc5822303d30