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Comparative evaluation of the wound-healing potency of recombinant bFGF and ski gene therapy in rats
- Source :
- Growth Factors. 34:119-127
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- We previously demonstrated that cellular Sloan-Kettering Institute (c-Ski) played a dual role, both promoting wound healing and alleviating scar formation. However, its mechanism and therapeutic effects are not clear, especially compared with widely used treatments, such as basic fibroblast growth factor (bFGF) administration. However, Ski treatment led to an even shorter healing time and a more significant reduction in scar area than bFGF treatment. The mechanism underlying this difference was related to a reduced inflammatory response, more rapid re-epithelialization, less collagen after healing and a greater reduction in the proportion of alpha-smooth muscle actin and SMemb-positive cells after Ski treatment. These results not only confirm that Ski plays a dual role in promoting healing and reducing scarring but also suggest that Ski yields better treatment effects than bFGF, indicating better potential therapeutic effects in wound repair.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Genetic enhancement
Clinical Biochemistry
Basic fibroblast growth factor
Pharmacology
law.invention
Comparative evaluation
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
law
Proto-Oncogene Proteins
Animals
Medicine
Potency
Rats, Wistar
Muscle actin
Wound Healing
business.industry
Therapeutic effect
Genetic Therapy
Cell Biology
Actins
Recombinant Proteins
Rats
Surgery
030104 developmental biology
chemistry
Recombinant DNA
Female
Fibroblast Growth Factor 2
Collagen
business
Wound healing
human activities
Subjects
Details
- ISSN :
- 10292292 and 08977194
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Growth Factors
- Accession number :
- edsair.doi.dedup.....afa77a210188877fc73204d1dc7449cf