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Discrepancy Between Body Surface Area and Body Composition in Cancer
- Source :
- Nutrition and Cancer. 65:1151-1156
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- Calculation of cytostatic dose is typically based on body surface area (BSA) regardless of body composition. The aim of this study was to assess the discrepancy between BSA and low fat-free mass (FFM) by investigating the prevalence of low FFM with regard to BSA in 630 cancer patients. First, BSA was calculated according to DuBois and DuBois. Patients were divided into 6 categories with respect to their BSA. Each BSA category was further divided into 3 groups according to FFM: low (-1 SD of mean FFM), normal (-0.99 and 0.99 SD of mean FFM) or high (1 SD of mean FFM), which was derived through bioelectric impedance analysis. FFM was reduced in 15.7% of patients, 69% had normal and 15.2% had high FFM. In patients with low FFM (i.e., more than-1 SD lower than the mean FFM within their BSA group), body mass index and fatigue were higher whereas functional status was reduced. Moreover, in the subcohort of patients receiving chemotherapy, absolute FFM [Hazard ratio (HR) = 0.970, P = 0.026] as well as the allocation to the low FFM group (HR = 1.644, P = 0.025) emerged as predictors of increased 1-yr mortality. In conclusion, there was a large discrepancy between FFM and BSA. Particularly women were affected by low FFM.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Body Surface Area
Urology
Medicine (miscellaneous)
Antineoplastic Agents
Body Mass Index
Drug Therapy
Neoplasms
Electric Impedance
medicine
Humans
In patient
Prospective Studies
Prospective cohort study
Aged
Proportional Hazards Models
Body surface area
Nutrition and Dietetics
Dose-Response Relationship, Drug
business.industry
Body Weight
Hazard ratio
Cancer
Middle Aged
medicine.disease
Body Height
Surgery
Cross-Sectional Studies
Adipose Tissue
Oncology
Body Composition
Female
Functional status
business
human activities
Body mass index
Bioelectrical impedance analysis
Subjects
Details
- ISSN :
- 15327914 and 01635581
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Nutrition and Cancer
- Accession number :
- edsair.doi.dedup.....af7b69a83048dc861fc395e15c5227cb