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Nanoporous anodic alumina reduces Staphylococcus biofilm formation
- Source :
- Letters in Applied Microbiology. 69:246-251
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Staphylococcus epidermidis and Staphylococcus aureus, two bacterial strains commonly associated with biofilm-related medical infections and food poisoning, can rapidly colonize biotic and abiotic surfaces. The present study investigates the ability of anodic alumina surfaces with nanoporous surface topography to minimize the attachment and biofilm formation mediated by these pathogenic bacterial strains. Early attachment and subsequent biofilm development were retarded on surfaces with nanopores of 15-25 nm in diameter compared to surfaces with 50-100 nm pore diameter and nanosmooth surfaces. After 30 min of incubation in nutritive media, the biomass accumulation per unit surface area was 2·93 ± 1·72 µm3 µm-2 for the 15 nm, 3·49 ± 1·97 µm3 µm-2 for the 25 nm, as compared to 14·04 ± 6·39 µm3 µm-2 for the nanosmooth, 11·88 ± 9·72 µm3 µm-2 for the 50 nm and 12·09 ± 11·84 µm3 µm-2 for the 100 nm surfaces respectively. These findings suggest that anodic alumina with small size nanoscale pores could reduce the incidence of staphylococcal biofilms and infections, and shows promise as a material for a variety of medical applications and food contact surfaces. SIGNIFICANCE AND IMPACT OF THE STUDY: This paper reports on a simple, robust and scientifically sound method to reduce attachment and biofilm formation by Staphylococcus aureus and Staphylococcus epidermidis to abiotic surfaces using a carefully designed nanoscale topography. This approach can help to reduce the incidence of staphylococcal biofilms and infections without imposing selective stresses on bacteria, thus preventing the creation of resistant strains.
- Subjects :
- 0106 biological sciences
Staphylococcus aureus
Nanostructure
medicine.disease_cause
01 natural sciences
Applied Microbiology and Biotechnology
Bacterial Adhesion
Biofouling
Nanopores
03 medical and health sciences
Staphylococcus epidermidis
010608 biotechnology
Aluminum Oxide
medicine
0303 health sciences
biology
030306 microbiology
Nanoporous
Chemistry
Biofilm
Staphylococcal Infections
biology.organism_classification
Chemical engineering
Biofilms
Staphylococcus
Bacteria
Subjects
Details
- ISSN :
- 1472765X and 02668254
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Letters in Applied Microbiology
- Accession number :
- edsair.doi.dedup.....af56c5fc5ba725c1f672ddcbe20c8568
- Full Text :
- https://doi.org/10.1111/lam.13201