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Piperlongumine inhibits angiotensin IIāinduced extracellular matrix expression in cardiac fibroblasts
- Source :
- Journal of Cellular Biochemistry. 119:10358-10364
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Piperlongumine (PL), a single component isolated from Piper longum, has been reported to possess anti-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. However, its role in cardiac fibrosis remains to be clarified. Therefore, we determined the effects of PL on cardiac fibroblasts (CFs) proliferation, and extracellular matrix (ECM) production under angiotensin II (Ang II) conditions, and further investigated the underlying molecular mechanism. Our data revealed that PL inhibited the proliferation and migration of CFs induced by Ang II. In addition, PL blocked the transformation of CFs to myofibroblasts induced by Ang II, as well as decreased cellular reactive oxygen species (ROS) production and malondialdehyde level in Ang II-stimulated CFs. Furthermore, PL significantly suppressed the Ang II-increased phosphorylation of extracellular regulated protein kinase 1/2 (ERK1/2) in CFs. Taken together, the results of the current study demonstrated that PL inhibits Ang II-induced cell proliferation, migration, and ECM expression in CFs through the inactivation of the ERR1/2 signaling pathway. These data strongly suggest that PL may be a promising therapeutic candidate for the treatment of cardiac fibrosis.
- Subjects :
- MAP Kinase Signaling System
Cardiac fibrosis
030204 cardiovascular system & hematology
Biochemistry
Extracellular matrix
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cell Movement
Malondialdehyde
Extracellular
medicine
Animals
Humans
Phosphorylation
Myofibroblasts
Protein kinase A
Molecular Biology
Piperlongumine
Cell Proliferation
Cell growth
Angiotensin II
Cell Differentiation
Dioxolanes
Heart
Cell Biology
Fibroblasts
medicine.disease
Fibrosis
Extracellular Matrix
Rats
Cell biology
chemistry
030220 oncology & carcinogenesis
Signal transduction
Reactive Oxygen Species
Piper
Subjects
Details
- ISSN :
- 10974644 and 07302312
- Volume :
- 119
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Biochemistry
- Accession number :
- edsair.doi.dedup.....af4c861dd308c7a74843064a8e0ec5d6