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The role of polymorphonuclear leukocytes and oxygen-derived free radicals in experimental acute pancreatitis: mediators of local destruction and activators of inflammation
- Source :
- FEBS Letters. 461:268-272
- Publication Year :
- 1999
- Publisher :
- Wiley, 1999.
-
Abstract
- Using a retrograde infusion sodium taurocholate pancreatitis model in the rat treatment with oxygen radical scavengers or monoclonal anti-ICAM-1 antibody decreased tissue damage and polymorphonuclear leukocytes (PMN) infiltration. Scavengers or anti-ICAM-1 treatment attenuated the activating capacity of blood PMNs following zymosan stimulation. The local production of oxygen free radicals in the pancreas by systemic infusion of hypoxanthine and regional infusion of xanthine oxidase did not induce acute pancreatitis, although an increase of infiltrating PMNs was observed. Our data suggest that oxygen free radicals and infiltrating PMNs aggravate acute pancreatitis and that both are important mediators of local destruction and systemic activation of PMNs.
- Subjects :
- Male
Xanthine Oxidase
Free Radicals
Neutrophils
Biophysics
Inflammation
Stimulation
Pharmacology
Biochemistry
chemistry.chemical_compound
Structural Biology
Genetics
medicine
Animals
Rats, Wistar
Xanthine oxidase
Molecular Biology
Hypoxanthine
Polymorphonuclear leukocyte
Superoxide Dismutase
Zymosan
Antibodies, Monoclonal
hemic and immune systems
Free Radical Scavengers
Cell Biology
Oxygen radical
Catalase
Intercellular Adhesion Molecule-1
medicine.disease
Rats
Pancreatitis
chemistry
Acute Disease
Acute pancreatitis
medicine.symptom
Reactive Oxygen Species
Infiltration (medical)
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 461
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....af4c77819564878bdd35a39d3c49a791