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Carotid Atherosclerosis, Cerebrospinal Fluid Pressure, and Retinal Vessel Diameters: The Asymptomatic Polyvascular Abnormalities in Community Study
- Source :
- PLoS ONE, Vol 11, Iss 12, p e0166993 (2016), PLoS ONE
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- Purpose To assess relationships between carotid artery atherosclerosis and retinal arteriolar and venular diameters. Methods The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) included a sub-population of the Kailuan study which consisted of 101,510 employees and retirees of a coal mining industry. Based on the Chinese National Census 2010 and excluding individuals with history of cerebrovascular ischemic events, 4004 individuals were included into the APAC. All participants underwent a detailed clinical examination including blood laboratory tests and carotid artery duplex ultrasound examination. The cerebrospinal fluid pressure (CSFP) was estimated using the formula: CSFP[mmHg] = 0.44xBody Mass Index[kg/m2]+0.16xDiastolic Blood Pressure[mmHg]–0.18 x Age[Years]–1.91. Results In multivariable analysis (goodness of fit r2:0.12), thicker retinal arteries were associated with a thinner common carotid artery intima-media thickness (IMT) (P = 0.002; standardized regression coefficient beta:-0.06; non-standardized regression coefficient B:-6.92;95% confidence interval (CI):-11.2,-2.61) after adjusting for thicker retinal nerve fiber layer (P
- Subjects :
- Carotid Artery Diseases
Male
Pathology
Physiology
Retinal Artery
Cerebral arteries
lcsh:Medicine
Blood Pressure
030204 cardiovascular system & hematology
Vascular Medicine
Carotid Intima-Media Thickness
chemistry.chemical_compound
Nerve Fibers
0302 clinical medicine
Venules
Animal Cells
Cerebrospinal Fluid Pressure
Medicine and Health Sciences
Common Carotid Arteries
Medicine
Common carotid artery
lcsh:Science
Neurons
Multidisciplinary
Arteries
Hematology
Middle Aged
Body Fluids
Blood
Carotid Arteries
Community Medicine
Cardiology
Female
Anatomy
Cellular Types
medicine.symptom
Research Article
Adult
medicine.medical_specialty
Retinal Vein
Carotid Artery, Common
Ocular Anatomy
Asymptomatic
Retina
03 medical and health sciences
Ocular System
medicine.artery
Internal medicine
Retinal Vein Occlusion
Humans
business.industry
lcsh:R
Biology and Life Sciences
Retinal Vessels
Retinal
Cell Biology
Cerebral Arteries
Blood pressure
chemistry
Cellular Neuroscience
Asymptomatic Diseases
Multivariate Analysis
Cardiovascular Anatomy
030221 ophthalmology & optometry
Blood Vessels
lcsh:Q
Cerebrospinal fluid pressure
business
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....af478205432cc8328b8661f21699ec94