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Genetic Engineering of T Cells for Immune Tolerance
- Source :
- Molecular Therapy. Methods & Clinical Development, Molecular Therapy: Methods & Clinical Development, Vol 16, Iss, Pp 103-107 (2020)
- Publication Year :
- 2019
- Publisher :
- American Society of Gene & Cell Therapy, 2019.
-
Abstract
- Regulatory T cells (Tregs) play a role in the induction and maintenance of tolerance, as well as in modulating aberrant immune responses. While expanded Tregs have been used in clinical trials, they are polyclonal and the frequency of specific Tregs is very low. To overcome this issue, we have endeavored to “specify” Tregs by engineering them to express receptors that can recognize a given antigen and applied this protocol in autoimmunity, hemophilia and allergy. Thus, we have used retroviral transduction of a specific T cell receptor, single-chain variable fragments (Fvs), or antigen domains in Tregs to achieve this goal. This review summarizes our steps to achieve the ultimate goal of modulating human diseases.
- Subjects :
- 0301 basic medicine
Allergy
lcsh:QH426-470
chemical and pharmacologic phenomena
medicine.disease_cause
Article
Autoimmunity
Immune tolerance
03 medical and health sciences
0302 clinical medicine
Immune system
Antigen
Genetics
medicine
lcsh:QH573-671
Receptor
Molecular Biology
biology
lcsh:Cytology
hemic and immune systems
medicine.disease
3. Good health
lcsh:Genetics
030104 developmental biology
Polyclonal antibodies
030220 oncology & carcinogenesis
Immunology
biology.protein
Molecular Medicine
Retroviral transduction
Subjects
Details
- Language :
- English
- ISSN :
- 23290501
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Molecular Therapy. Methods & Clinical Development
- Accession number :
- edsair.doi.dedup.....af3e770bc8babb87d66a86ed4d63f49d