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Birth Outcomes and Prenatal Exposure to Ozone, Carbon Monoxide, and Particulate Matter: Results from the Children’s Health Study
- Source :
- Environmental Health Perspectives
- Publication Year :
- 2005
- Publisher :
- National Institute of Environmental Health Sciences, 2005.
-
Abstract
- Exposures to ambient air pollutants have been associated with adverse birth outcomes. We investigated the effects of air pollutants on birth weight mediated by reduced fetal growth among term infants who were born in California during 1975-1987 and who participated in the Children's Health Study. Birth certificates provided maternal reproductive history and residence location at birth. Sociodemographic factors and maternal smoking during pregnancy were collected by questionnaire. Monthly average air pollutant levels were interpolated from monitors to the ZIP code of maternal residence at childbirth. Results from linear mixed-effects regression models showed that a 12-ppb increase in 24-hr ozone averaged over the entire pregnancy was associated with 47.2 g lower birth weight [95% confidence interval (CI), 27.4-67.0 g], and this association was most robust for exposures during the second and third trimesters. A 1.4-ppm difference in first-trimester carbon monoxide exposure was associated with 21.7 g lower birth weight (95% CI, 1.1-42.3 g) and 20% increased risk of intrauterine growth retardation (95% CI, 1.0-1.4). First-trimester CO and third-trimester O3 exposures were associated with 20% increased risk of intrauterine growth retardation. A 20-microg/m3 difference in levels of particulate matter < or = 10 microm in aerodynamic diameter (PM10) during the third trimester was associated with a 21.7-g lower birth weight (95% CI, 1.1-42.2 g), but this association was reduced and not significant after adjusting for O3. In summary, O3 exposure during the second and third trimesters and CO exposure during the first trimester were associated with reduced birth weight.
- Subjects :
- Male
Health, Toxicology and Mutagenesis
air pollution
010501 environmental sciences
01 natural sciences
California
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
11. Sustainability
Childbirth
Birth Weight
030212 general & internal medicine
Air Pollutants
Fetal Growth Retardation
Obstetrics
Dust
Particulates
intrauterine growth retardation
3. Good health
Children's Health
Female
medicine.symptom
Adult
medicine.medical_specialty
Ozone
nitrogen dioxide
Birth weight
carbon monoxide
03 medical and health sciences
Air pollutants
maternal exposure
medicine
Humans
Particle Size
0105 earth and related environmental sciences
particulate matter
business.industry
Research
Public Health, Environmental and Occupational Health
Infant, Newborn
Infant, Low Birth Weight
medicine.disease
Confidence interval
Low birth weight
chemistry
13. Climate action
business
Subjects
Details
- Language :
- English
- ISSN :
- 15529924 and 00916765
- Volume :
- 113
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Environmental Health Perspectives
- Accession number :
- edsair.doi.dedup.....af3a2aacaa5c8c45281e1fb66686db85