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An outbreak of peritonitis caused by multidrug-resistant Salmonella typhi in Kinshasa, Democratic Republic of Congo
- Publication Year :
- 2009
-
Abstract
- Summary Between October 2004 and January 2005, 144 patients with peritonitis were admitted to the surgical wards of Kinshasa General Hospital and a few private city clinics. 63 patients (44%) underwent surgical intervention because of intestinal perforation consistent with typhoid fever; the case fatality rate was 53%. The majority of patients had received a course of first-line antibiotics such as chloramphenicol, ampicillin or co-trimoxazole before admission. On bacteriological investigation, Salmonella Typhi was isolated from the blood of 11 patients with peritonitis. The isolates were all resistant to ampicillin, chloramphenicol, tetracycline and co-trimoxazole, but sensitive to third-generation cephalosporins, quinolone (nalidixic acid, ciprofloxacine) and amoxicillin-clavulanic acid. Several factors contributed to the poor outcome of this disease including a) the use of inappropriate antibiotics, b) long delay in diagnosis, c) difficult access to health facilities. This is the first documented outbreak of typhoid fever caused by a multidrug-resistant S. Typhi in Kinshasa.
- Subjects :
- Adult
Male
Case fatality rate
medicine.medical_specialty
Adolescent
Nalidixic acid
Perforation (oil well)
Bacterial diseases
Colony Count, Microbial
Peritonitis
Microbial Sensitivity Tests
Multidrug resistance
Salmonella typhi
Typhoid fever
Disease Outbreaks
Microbiology
Young Adult
Drug Resistance, Multiple, Bacterial
Ampicillin
Internal medicine
medicine
Humans
Africa, Central
Child
Dose-Response Relationship, Drug
business.industry
Clinical management
Public Health, Environmental and Occupational Health
Outbreak
medicine.disease
Anti-Bacterial Agents
Congo-Kinshasa
Treatment Outcome
Infectious Diseases
Diagnosis delay
Democratic Republic of the Congo
Female
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....af39dacc5186f005f114fa50b85cc2dd
- Full Text :
- https://doi.org/10.1016/j.tmaid.2008.12.006