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A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report
- Source :
- Hand and Microsurgery, Vol 5, Iss 2, Pp 62-69 (2016)
- Publication Year :
- 2016
- Publisher :
- ScopeMed, 2016.
-
Abstract
- Objectives: Treatments of long peripheral nerve defects are limited and a means to construct a vascularized nerve graft substitute has been sought. Material and Methods: An in vivo chamber bioreactor was designed with the White New Zealand rabbit's superficial inferior epigastric pedicle (SIEP) and using autologous Schwann cell (ASC) suspension, a tissue volume containing rich vascularization and a dense presence of Schwann cells was constructed. This construct was comparatively tried on 3 cm of a sciatic nerve defect. Results: A vascularized build with rich blood supply and an abundance of Schwann cells was engineered and utilized for nerve regeneration and transmission, axonal passage being displayed. Conclusion: According to the literature review, this is the first achievement of engineering a nerve graft substitute containing vascularized Schwann cells. Therefore, it is believed this study has yielded significant preliminary results, providing a basis for future studies. [Hand Microsurg 2016; 5(2.000): 62-69]
- Subjects :
- cell culture
Future studies
business.industry
Regeneration (biology)
lcsh:Surgery
Nerve graft
Schwann cell
vascularized nerve graft
lcsh:RD1-811
Anatomy
autologous schwann cells
medicine.anatomical_structure
In vivo
Preliminary report
tissue engineering
medicine
Bioreactor
Sciatic nerve
business
Peripheral nerves
Biomedical engineering
Subjects
Details
- ISSN :
- 24587834
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Hand and Microsurgery
- Accession number :
- edsair.doi.dedup.....af33ed0d7dd09583c789d55edffdf719